Antibiotics have saved many people’s lives, but the proliferation of antibiotics has also ruined countless families. It is still difficult to agree on how much to use. Some people can only use antibiotics, and some people can use alternative medicines. The use of antibiotics has always been controversial.
A recent study by the University of Pittsburgh School of Medicine showed that when antibiotics are used to treat 9 to 23-month-old infants with otitis media, a shortened course of treatment affects clinical outcomes and does not reduce antibiotic resistance and other undesirableities. The risk of reaction.
Is it shorter to shorten the treatment cycle?
Acute otitis media is an infection caused by pathogenic bacteria, which is especially common during infants and young children, and is the most common cause of exposure to antibiotics in infants and young children. Due to public concerns about excessive use of antibiotics and resistance to this, the University of Pittsburgh School of Medicine and the Children’s Hospital of the Medical Center conducted a joint trial to explore the effect of shortening the antibiotic use cycle on treatment outcomes and whether it would reduce resistance. And the risk of causing adverse reactions.
In the trial, 520 infants with acute otitis media were randomly assigned to two treatment options. One is the 10 day standard treatment with the anti-infective drug amoxicillin and clavulanate potassium, one is 5 anti-infective plus 5 day placebo. The physicians and patients participating in the trial did not know the specific grouping.
A one-year follow-up observation showed that the 5 day antibiotic regimen had a treatment failure rate of 34%, more than twice the 10 day antibiotic regimen, and the latter had a failure rate of only 16%. In addition, the test results show that the 5 antibiotic treatment regimen does not reduce the risk of antibiotic resistance in children, nor does it reduce the risk of adverse reactions such as diarrhea and diaper rash.
Thus, the independent safety oversight committee responsible for monitoring the trial concluded that the trial results have shown that the 10 day antibiotic regimen is significantly better than the 5 day regimen.
The study also found for the first time that the risk of re-infection of children with acute otitis media with pus residual in the middle ear after treatment is as high as 50%, much higher than children without pus residuals.
For the use of antibiotics, it can still be used as little as possible. But it is not certain that it cannot be used. The premise of doctors’ treatment is to ensure the patient’s treatment effect. If it can’t be cured, it is necessary to distinguish whether to use antibiotics.
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